The core duodenal microbiome was different in HT− participants ( n = 12) when compared with RA participants ( n = 10), but more similar in HT+ ( n = 13) and RA participants. Serum hormone levels were analyzed by Luminex FlexMap. V3 and V4 libraries were used for 16S rRNA sequencing. DNAs were isolated from duodenal aspirates obtained during upper endoscopy. Methods:įemale participants undergoing esophagogastroduodenoscopy who were postmenopausal and taking HT (HT+), postmenopausal but not taking HT (HT−), or of reproductive age and not taking exogenous hormones (RA), were identified and matched for body mass index (☓ kg/m 2). Here, we characterize duodenal microbiome differences, and the effects of HT, in postmenopausal women. The small intestine plays key roles in metabolic and endocrine function, but the effects of HT on the small intestinal microbiome are unknown. Hormone therapy (HT) is used to treat menopause-related conditions and symptoms. The work cannot be changed in any way or used commercially without permission from the journal.
CLC GENOMICS WORKBENCH 12 DARTMOUTH PDF
Direct URL citations are provided in the HTML and PDF versions of this article on the journal's Website ( This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. Supplemental digital content is available for this article. The datasets generated during this study are available at the National Center for Biotechnology Information (NCBI) BioProject Repository ( ) under BioProject ID PRJNA725496. E-mail: įunding/support: This study was supported in part by funds from the Monica Lester Charitable Trust and the Elias, Genevieve, and Georgianna Atol Charitable Trust.įinancial disclosures/conflicts of interest: None reported. 1Medically Associated Science and Technology (MAST) Program, Cedars-Sinai, Los Angeles, CAĢKarsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai, Los Angeles, CAģDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars-Sinai, Los Angeles, CA.Īddress correspondence to: Ruchi Mathur, MD, Director, Clinical Diabetes, Cedars-Sinai Medical Center, 700 N San Vicente, Suite G271, West Hollywood, CA 90069.
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